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bupropion
Bupropion represents one of the more fascinating psychotropic agents in our modern arsenal—an atypical antidepressant that defies easy classification. Unlike the SSRIs that dominated the 1990s, bupropion operates through a completely different pathway, acting primarily as a norepinephrine-dopamine reuptake inhibitor (NDRI) with minimal serotonergic activity. This unique mechanism not only explains its distinct side effect profile but also its expanding off-label applications beyond major depressive disorder. I remember when we first started using it more regularly in our practice back in the early 2000s—we had this 42-year-old patient, Mark, who had failed two previous SSRI trials due to sexual side effects and weight gain.
Asendin: Effective Management of Treatment-Resistant Depression - Evidence-Based Review
Before we get to the formal monograph, let me give you the real story on Asendin. We’ve been working with this amoxapine formulation for about six years now, and honestly, the initial trial data looked almost too good. I remember our lead pharmacologist, Dr. Chen, kept saying “the receptor affinity profile looks like someone designed this in a lab specifically for treatment-resistant cases” – which of course someone did, but you know what I mean.
bupron sr
Bupropion SR, or sustained-release bupropion, represents one of those rare psychopharmacological innovations that actually changed how we approach depression treatment in clinical practice. Unlike the flood of me-too SSRIs that dominated the 90s, bupropion SR brought something genuinely different to the table - a novel mechanism targeting norepinephrine and dopamine without the serotonergic activity that caused so many side effects for our patients. I remember when we first started using it at our clinic, we were frankly skeptical about yet another antidepressant claim, but the distinct profile quickly won over even our most conservative prescribers.
celexa
Celexa, known generically as citalopram hydrobromide, is a selective serotonin reuptake inhibitor (SSRI) antidepressant medication, not a dietary supplement or medical device. It’s prescribed primarily for major depressive disorder (MDD) but has several off-label uses. The drug works by increasing serotonin levels in the brain, which helps improve mood, sleep, appetite, and energy levels. Available in tablet and oral solution forms, it requires a prescription and careful medical supervision due to potential side effects and drug interactions.
Champix: Effective Smoking Cessation Aid - Evidence-Based Review
Champix, known generically as varenicline, is a prescription medication specifically developed as a smoking cessation aid. It functions as a partial agonist on nicotinic acetylcholine receptors, essentially tricking the brain into thinking it has received nicotine, which reduces both withdrawal symptoms and the pleasure derived from smoking if a person does slip up and have a cigarette. It’s a cornerstone in the pharmacological approach to tackling nicotine addiction, representing a significant advancement over previous options like nicotine replacement therapy (NRT) or bupropion.
contrave
Contrave represents one of the more interesting pharmacological approaches to weight management we’ve seen in recent years—it’s not another stimulant-based appetite suppressant, but rather a combination product targeting the neurological pathways involved in food reward and craving. When I first reviewed the clinical trial data back in 2014, I was skeptical about the naltrexone/bupropion combination showing meaningful weight loss beyond placebo effects. But the consistency of the 5-10% total body weight loss across multiple trials made me reconsider the neurobiology of obesity.
desyrel
Desyrel represents one of those interesting cases where a medication developed for one purpose reveals unexpected therapeutic dimensions over time. Initially introduced as an antidepressant, we’ve gradually understood its complex pharmacodynamics extend far beyond mood regulation into areas like sleep architecture modulation and chronic pain management. The journey from standard antidepressant to multifaceted therapeutic agent reflects how our understanding of neuropharmacology continues to evolve. ## 1. Introduction: What is Desyrel? Its Role in Modern Medicine
Effexor XR: Dual Neurotransmitter Modulation for Treatment-Resistant Depression - Evidence-Based Review
Effexor XR is an extended-release formulation of venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI) primarily indicated for major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. Unlike immediate-release formulations, the extended-release delivery system provides stable plasma concentrations over 24 hours, which can enhance tolerability and adherence. The distinctive dual reuptake inhibition mechanism—affecting both serotonin and norepinephrine transporters—positions it uniquely among antidepressants, particularly for patients with inadequate response to selective serotonin reuptake inhibitors (SSRIs).
Fluoxetine: Effective Symptom Management for Mood and Anxiety Disorders - Evidence-Based Review
Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), stands as one of the most extensively studied and prescribed antidepressants globally. Initially approved by the FDA in 1987, it has fundamentally reshaped the landscape of psychiatric pharmacotherapy. Its significance extends beyond major depressive disorder, with robust evidence supporting its use across a spectrum of conditions from obsessive-compulsive disorder to premenstrual dysphoric disorder. The molecule’s unique pharmacokinetic profile, including a long half-life and an active metabolite, contributes to both its therapeutic benefits and its distinctive side effect and discontinuation syndrome profile.